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This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. For reprints contact: [email protected] Cite this article as: Mommaerts MY. Guidelines for patient-specific jawline definition with titanium implants in esthetic, deformity, and malformation surgery. Ann Maxillofac Surg 2016;6:287-91. Technical Note Mommaerts: 3D print for jawline Annals of Maxillofacial Surgery | July December 2016 | Volume 6 | Issue 2 288 to three screws.[3] The pterygomasseteric sling was reconstructed on closure, but the final results were not quantified. Yaremchuk described a series of 11 cases with transorally placed porous ethylene implants (Medpore®), also increasing posterior height and using transbuccal screw fixation.[4] Bastidas and Zide warned against vertical lengthening, frankly stating that “the masseter cannot be lengthened.”[5] They felt that porous polyethylene or silicone implants should not be placed through a facelift incision or Risdon approach, as the pterygomasseteric sling will be disrupted, causing the masseter to bulge on clenching and exposing the lower border of the implant (also demonstrated by Thomas and Yaremchuk[6]). They too advocated screw fixation. Even with the advantage of screw fixation, asymmetrical results and infectious complications remain issues for many facial surgeons and are reasons not to perform implantation at this visible site. With the advent of additive manufacturing, software is now available that allows precise preoperative design on segmented computerized tomography data using mirroring techniques (3‐matic®, Materialise, Heverlee, Belgium; Geomagic Freeform Plus®, 3D Systems, Darmstadt, Germany). This is particularly useful for bilateral esthetic features such as jaw angles and jawlines. The aim of this study was to present clinically interesting design requirements for jawline demarcation using titanium implants manufactured by selective laser melting (SLM). SUBJECTS AND METHODS Preoperative planning Anthropometrical guidelines Assessing abnormalities and planning corrections are not easy tasks when a patient presents with symmetrical hypoplasia. A proper substrate is missing. Constructs can be made on frontal and profile clinical pictures of a face and compared with ideal proportions and inclinations. Contemporary guidelines exist for men, not for women.[7] For female patients, another approach is more attractive. Women can usually describe which celebrity’s angle or jawline they desire. If the surgeon is lucky, a pure profile or frontal picture of that celebrity is available on the Internet. The patient’s and celebrity’s pictures can be superimposed, and the difference provides an idea of the desired corrections, even down to the millimeter [Figure 1].[8] Soft‐to‐hard tissue ratios have not been published for this sensitive three‐dimensional (3D) area. We simply assume that 1 mm of hard tissue augmentation results in 1 mm of soft tissue augmentation in lateral and vertical directions. This has to be handled with caution, but it provides at least an impression that can be discussed with the patient. Technical design guidelines Fibrosis and a scarred buccal vestibule from multiple orthognathic, reconstructive, and/or implantation surgeries may prompt a surgeon to access the mandibular border through a submandibular approach. In the present series, the author was not tempted or urged to do so. When choosing the transoral route, maximal interincisal mouth opening, reduced intercommissure width, and reduced lip elasticity may pose a problem when considering voluminous implants. This is often the case in hemifacial microsomia patients for whom orthognathic surgery, ramus reconstruction, and macrostomia correction have been previously undertaken.[9] Inserting voluminous implants may also jeopardize the mental nerve, especially when they extend below the mental foramen. For both of these reasons, splitting the implant in two parts may be considered. The posterior and anterior segments can be positioned with a front‐to‐back and back‐to‐front action, respectively. The tip of the implant is slipped under the mental foramen after subperiosteal dissection of this area has been undertaken through the extension of the buccal incision into the labial vestibule [Figure 2]. Precise reassembling of the two segments within the wound cavity is best performed with an interlocking design, such as a 3D puzzle connection.[10] The use of one or two 3D puzzle connections does not make a difference in the author’s experience [Figure 2]. However, an oversized 3D design may hamper insertion of the second segment because more lateral soft tissue stretch is required [Figure 3]. Mirroring a healthy side to a deficient one may prompt the designer to simulate the cranial part accordingly large. This is less important for jawline definition and may be the cause of wound dehiscence, so it is wise to compromise. The implant may straddle the lower border halfway; however, the surgeon should not be forced to strip the pterygomasseteric sling to set the implant tight on the border. Porosities (scaffolding) are useful where there is bony contact [Figure 4]. The friction provides primary stability as with any screw‐fixed plate.[11] Porosities >500 μm are osteoinductive. Fukuda et al. demonstrated osteoinduction as deep as 5 mm in channels with a diameter of 500 μm or more within SLM‐manufactured titanium implants placed in a nonosseous site, namely, the dorsal muscles of Beagle dogs.[12] Scaffolding increases the overall elasticity to more closely approximate that of bone[13] and therefore reduces stress shielding and premature loosening of an implant fixed to the weight‐bearing mandible. It also helps in weight reduction. Hence, it makes sense to biofunctionalize the area of bony contacts using scaffolds with a diamond unit cell structure ≥500 μm for a few millimeters deep. Sandblasting and acid etching further promote osteoconductivity.[14] The lateral surface is micro‐shot‐peened (250‐μm Al2O3 broken beads) to obtain a satin” finish with a roughness average of N7–N10. A highly polished surface may discourage periosteum reattachment, whereas a very rough surface may encourage bacterial growth when contamination with saliva occurs.[15] Two screws per implant segment are necessary for proper fixation. Masseter muscle action may otherwise dislocate the posterior segment. In the author’s experience, a single screw in an anterior segment may not prevent rotation. The screw holes are designed with respect to the inferior alveolar nerve using image segmentation software (Mimics Medical 19.0, Mimics Innovation Suite, Materialise, Heverlee, Belgium). Depending on the location of the implant and the estimated freedom of access, screw holes are provided in the implant body or lip extensions [Figure 4]. The extensions are also used to refer Mommaerts: 3D print for jawline Annals of Maxillofacial Surgery | July December 2016 | Volume 6 | Issue 2 289 to anatomical structures (e.g., molars) for improved initial orientation. When in the jaw angle area, the author recommends providing holes for both the transoral and transbuccal approach, with the latter as a rescue measure [Figure 5]. Countersinking is not required. The author prefers screws with external pentagon‐shaped heads (2.3‐mm diameter; Surgi‐Tec NV, Gent, Belgium) that facilitate screw removal during placement or eventually on explantation. Although implant augmentation of the chin initially seems to be a logical extension of the lateral augmentation, the author prefers a chin osteotomy when chin augmentation is required. With an osseous genioplasty, height reduction can also be obtained. With the advancement of the lower mandibular border, the digastric and geniohyoid muscles are stretched with a positive functional (increase of airway) and esthetic (decrease of mentocervical angle) effect on hyoid position. Jawline augmentation with titanium implants and chin osteotomy can be done simultaneously [Figure 6]. The choice of titanium over polyetheretherketone (PEEK) is based on the European belief that it is better to prevent long‐term complications caused by nonosseointegrated PEEK implants than to handle those complications associated with osseointegrated titanium (Federal and Drug Administration philosophy). Operative technique The intraoral approach to the jaw angle is made with an incision based on the external oblique line, extending anteriorly, staying 1 cm above the lower recess of the vestibule, and avoiding the long buccal nerve. Anterior extension continues into the lower lip when the jowl area also needs correction or when voluminous angle implants are placed. A high incision is likely to minimize postoperative saliva spillage into the wound. Watertight closure of the oral mucosal membrane is difficult to guarantee. Figure 3: Medial part of a left‐sided jaw border implant in two parts with a large three‐dimensional puzzle design. Each part has two holes for screw fixation. The scaffolding is clearly visible Figure 2: Rendering of a two‐part implant on the lateral mandibular border extending below the mental foramen (Geomagic Freeform Plus®) (a) mandibular shape after two orthognathic surgeries and one chin osteotomy, (b) implant design in two parts, (c) connected double three‐dimensional puzzle design, (d) anterior part showing the disconnected double three‐dimensional puzzle design, (e) Backside of the three‐dimensional printed and biofunctionalized assembly, with three‐dimensional puzzle design d c b a Figure 4: Left (a) and right (b) single‐piece jaw implants designed to extend inferiorly. The extension lips each have two screw holes. Porosities are provided where bone will come in contact. The periphery and lateral surface is “satin” finished to prevent contamination from saliva b a Figure 1: Photoshop simulation (c) of the jaw angle of Kim Kardashian (b) onto a patient’s original facial profile (a) After jaw angle implantation (d) (Courtesy Dr. N. Loomans) d c b a Enlarging the wound cavity for augmentation inferior and/or posterior to the mandibular border can be performed by dry gauze packing rather than with sharp dissection. Uniform expansion with gauze will lead to periosteum distention and pocket formation rather than perforations. This protects the mandibular branch of the facial nerve in hemifacial microsomia cases, where its course is unpredictable. It also prevents opening the superficial neck to the oral cavity. Intraoperative 3D imaging (e.g., with the BV Pulsera Fluoroscopy System, Philips Medical, Eindhoven, The Netherlands) will confirm correct positioning. Infection control is further maintained by copious wound rinsing, rinsing the implant in rifampicin solution, double‐layer Mommaerts: 3D print for jawline Annals of Maxillofacial Surgery | July December 2016 | Volume 6 | Issue 2 290 Aiache[2] mentioned double closure over silicone implants, and Yaremchuk[4] mentioned “a generous intraoral mucosal incision 1 cm high in the sulcus at its labial side,” to which the author now adheres. In Whitaker’s[1] experience, autologous (calvarial bone) onlays and sandwich osteotomies yielded unpredictable results because of resorption and symmetry issues, and he discontinued their use. Triaca et al.[19] used an extended chin osteotomy using frequent Figure 5: Planning of screw hole placement below the mandibular canal: The upper and lower sets are for transoral and transbuccal fixation, respectively. (Rendering of skull and right‐sided implant of patient of Figure 1) Figure 6: A rescue orthognathic case after bimaxillary surgery and condylar resorption with loss of jaw angle definition and increased anterior facial height. Jaw angle reconstruction was performed together with a chin osteotomy (red arrow) with advancement and height reduction. The extension lips are depicted (white arrows) with reference to the distal side of the last molars Figure 7: An esthetic case before (a) and after (b) bilateral jaw angle implantation. Although the implants were rather small (c), the demarcation between the face and neck by surgical definition of the mandibular angle can be well appreciated b a c closure (i.e., horizontal running mattress suture for deep approximation and eversion, superficial running for the epithelial border approximation), application of fibrin glue (Tisseel, Baxter) under the suture line, and 5 days of penicillin perorally.